Description

Arp 101 is a high-purity, small molecule compound identified by CAS NO 849773-63-3, primarily utilized as a potent and selective antagonist for the Retinoic Acid Receptor-related Orphan Receptor Gamma (RORγt). This compound is critical for researchers and developers targeting autoimmune and inflammatory pathways, offering a valuable tool for modulating T-helper 17 (Th17) cell differentiation and function. It serves as an essential research chemical in pharmaceutical R&D, particularly for investigating novel therapeutics for conditions like psoriasis, rheumatoid arthritis, and multiple sclerosis.

Application

• Pharmaceutical Research & Development: A key reference standard and active pharmacological agent in the discovery and validation of RORγt-targeted therapies.
• Immunology Studies: Used to investigate the role of the RORγt pathway in Th17 cell biology, cytokine production, and autoimmune disease mechanisms.
• Biochemical Assays: Employed as a selective inhibitor in high-throughput screening (HTS), binding assays, and functional cellular assays to characterize compound activity.
• Preclinical Development: Supports in vitro and in vivo studies to evaluate the efficacy, pharmacokinetics, and safety profiles of novel immunomodulators.
• Academic Research: Provides a reliable tool for universities and research institutes studying transcriptional regulation and immune system function.

Basic Information

Product Name	Arp 101
CAS No.	849773-63-3
Molecular Formula	C₂₀H₂₀F₃N₃O₃S
Molecular Weight	439.45 g/mol
Synonyms	N-(4-(4-(Ethylsulfonyl)phenyl)-5-methylthiazol-2-yl)-2-(trifluoromethyl)benzamide; RORγt Inverse Agonist; RORγt Antagonist ARP-101; GSK805; (2-(Trifluoromethyl)-N-[4-[4-(ethylsulfonyl)phenyl]-5-methyl-1,3-thiazol-2-yl]benzamide); ARP101; ARP 101.
EINECS	Contact for details

Quality Control

Every batch of Arp 101 (CAS 849773-63-3) is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation, meeting the stringent requirements of research and development. Certificates of Analysis (COA) detailing purity, impurities, and analytical methods are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. The compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.