Description

Ethyl 2-(2-Fluoropyridin-3-Yl)-2-Oxoacetate is a high-purity fluorinated pyridine derivative and a key organic synthetic intermediate. This compound is valued for its reactive α-ketoester moiety adjacent to a fluorinated heterocyclic ring, enabling its use in the construction of complex pharmacophores. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the fluoropyridine scaffold contributes to biological activity and metabolic stability.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization, including condensation reactions, nucleophilic additions, and cyclizations to create diverse heterocyclic libraries.
• Material Science: Potential intermediate in the synthesis of specialty chemicals, ligands for catalysis, and advanced organic electronic materials.

Basic Information

Product Name	Ethyl 2-(2-Fluoropyridin-3-Yl)-2-Oxoacetate
CAS No.	849069-30-3
Molecular Formula	C9H8FNO3
Molecular Weight	197.16 g/mol
Synonyms	Ethyl 2-oxo-2-(2-fluoropyridin-3-yl)acetate; 2-(2-Fluoropyridin-3-yl)-2-oxoacetic Acid Ethyl Ester; Ethyl (2-fluoro-3-pyridinyl)oxoacetate; 849069-30-3; 2-Fluoropyridine-3-glyoxylic Acid Ethyl Ester; 3-Pyridineglyoxylic acid, 2-fluoro-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-(2-Fluoropyridin-3-Yl)-2-Oxoacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical quality attributes are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.