Description

6-Hydroxy-4-(Trifluoromethyl)Nicotinicacid is a high-value trifluoromethyl-substituted pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its unique structure, combining a carboxylic acid group with a hydroxy and a trifluoromethyl substituent on the pyridine ring, makes it an essential intermediate for creating compounds with enhanced metabolic stability and bioavailability. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials due to its electron-withdrawing characteristics.
• Chemical Biology Probes: Utilized to develop molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	6-Hydroxy-4-(Trifluoromethyl)Nicotinicacid
CAS No.	849020-87-7
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	4-(Trifluoromethyl)-6-hydroxynicotinic acid; 6-Hydroxy-4-(trifluoromethyl)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 6-hydroxy-4-(trifluoromethyl)-; 849020-87-7; 6-Hydroxy-4-trifluoromethylnicotinic acid; 4-Trifluoromethyl-6-hydroxynicotinic acid; 6-Hydroxy-4-(trifluoromethyl)nicotinic acid
EINECS	Contact for details

Quality Control

Our 6-Hydroxy-4-(Trifluoromethyl)Nicotinicacid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.