Description

Fgfr Inhibitor CAS NO 848463-13-8 is a potent and selective small molecule inhibitor targeting the Fibroblast Growth Factor Receptor (FGFR) family of tyrosine kinases. This compound is a critical research tool and a key intermediate in the development of targeted cancer therapeutics, particularly for cancers driven by FGFR pathway dysregulation. It is essential for pharmaceutical R&D, academic research in oncology, and the synthesis of novel investigational drugs.

Application

• Pharmaceutical Research & Development: Serves as a primary reference standard and a key pharmacologically active ingredient in the discovery and development of novel anti-cancer drugs.
• Biochemical Assay Development: Used as a selective inhibitor to study FGFR signaling pathways, enzyme kinetics, and cellular mechanisms in vitro.
• Preclinical Studies: Employed in animal models to evaluate the efficacy, pharmacokinetics, and toxicity profiles of FGFR-targeted therapeutic candidates.
• Chemical Synthesis Intermediate: Acts as a crucial building block for the synthesis of more complex FGFR inhibitor analogs and derivatives with optimized properties.
• Academic & Institutional Research: Utilized in universities and research institutes to investigate the role of FGFR in cell proliferation, differentiation, and disease progression.

Basic Information

Product Name	Fgfr Inhibitor CAS NO 848463-13-8
CAS No.	848463-13-8
Molecular Formula	C₂₁H₂₀N₈O₃S
Molecular Weight	464.50 g/mol
Synonyms	NVP-BGJ398; BGJ398; BGJ 398; 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-[4-(4-ethylpiperazin-1-yl)phenylamino]pyrimidin-4-yl}-1-methylurea; Infigratinib phosphate intermediate; FGFR Inhibitor BGJ398; Fibroblast Growth Factor Receptor Inhibitor
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical development. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and potency. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We adhere to strict quality management protocols to ensure consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.