Description

Ex-527 (R-Enantiomer) is a high-purity, single-enantiomer small molecule inhibitor of significant interest in advanced pharmaceutical research and development. This compound matters as a selective and potent tool for studying specific biological pathways, offering researchers a critical reagent for target validation and drug discovery. It is primarily needed by R&D scientists and process chemists in the pharmaceutical, biotechnology, and academic sectors working on innovative therapeutic programs.

Application

• Pharmaceutical R&D as a key reference standard and active pharmaceutical ingredient (API) intermediate.
• Biochemical Research for in vitro and cellular assays to investigate specific enzyme inhibition and signaling pathways.
• Preclinical Studies utilized in animal models to evaluate pharmacokinetics, pharmacodynamics, and efficacy.
• Process Chemistry serving as a chiral building block or precursor in the synthesis of more complex target molecules.
• Analytical Method Development used as a certified standard for HPLC, LC-MS, and other analytical techniques.

Basic Information

Product Name	Ex-527 (R-Enantiomer)
CAS No.	848193-69-1
Molecular Formula	C19H19N3O2S
Molecular Weight	353.44 g/mol
Synonyms	EX-527; (R)-EX-527; (R)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide; SRT 1460; SRT1460; Sirtinol; SIRT1 Inhibitor III; Selisistat (R-enantiomer); 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (R-enantiomer)
EINECS	Contact for details

Quality Control

Our Ex-527 (R-Enantiomer) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We ensure compliance with relevant standards for research-grade materials, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.