Description

6-Bromo-2,3-Difluorotoluene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its value lies in its unique substitution pattern, which allows for selective and sequential functionalization, making it a critical intermediate for creating complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for developing new active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorine-containing drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the bromine and fluorine atoms contribute to enhanced biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorine-based electronic chemicals used in liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs) due to its influence on molecular polarity and stability.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form biaryl structures, a common motif in many functional materials.
• Functional Polymer Monomer: Employed in the synthesis of specialty polymers and resins with tailored properties such as thermal stability, chemical resistance, and specific optical characteristics.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic methodologies and constructing complex heterocyclic compounds.

Basic Information

Product Name	6-Bromo-2,3-Difluorotoluene
CAS No.	847502-81-2
Molecular Formula	C7H5BrF2
Molecular Weight	207.02 g/mol
Synonyms	1-Bromo-2,3-difluoro-4-methylbenzene; 2,3-Difluoro-6-bromotoluene; 4-Bromo-2,3-dimethylfluorobenzene (incorrect but common misnomer); Toluene, 6-bromo-2,3-difluoro-; 2,3-Difluoro-4-methylbromobenzene; 6-Bromo-2,3-difluoro-1-methylbenzene; Bromodifluorotoluene (unspecified isomer)
EINECS	Contact for details

Quality Control

Every batch of 6-Bromo-2,3-Difluorotoluene is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive in-process and final release testing, including identity confirmation, purity assay, and impurity profiling, is performed. Certificates of Analysis (COA) detailing all specifications and results are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider using an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.