Description

Smac Inhibitor 1 CAS NO 847256-33-1 is a potent, cell-permeable small molecule antagonist of the Inhibitor of Apoptosis Proteins (IAPs), specifically designed to mimic the N-terminal tetrapeptide of Smac/DIABLO. This compound is critical for inducing apoptosis in cancer cells by disrupting IAP-caspase interactions, thereby promoting programmed cell death. It is an essential research tool for oncology, biochemistry, and pharmaceutical development, particularly in the study of cancer therapeutics and apoptotic signaling pathways.

Application

• Oncology Research: Used as a key biochemical tool to study apoptosis resistance mechanisms and to screen for novel cancer therapeutics.
• Drug Discovery & Development: Serves as a lead compound or reference standard in the development of Smac mimetics and pro-apoptotic agents.
• Biochemical Assays: Employed in in vitro assays to investigate caspase activation and IAP protein function.
• Cell Biology Studies: Utilized to sensitize cancer cell lines to apoptosis induced by chemotherapeutic agents or TRAIL.
• Academic & Pharmaceutical R&D: A fundamental reagent for exploring cell death pathways and validating drug targets in research laboratories.

Basic Information

Product Name	Smac Inhibitor 1
CAS No.	847256-33-1
Molecular Formula	C₂₃H₂₃N₅O₃
Molecular Weight	417.46 g/mol
Synonyms	Smac Mimetic 1; Smac Inhibitor; (2S,3S,4R,5S)-2-(4-Chlorophenoxy)-3,4-dihydroxy-5-[4-(1H-indol-3-yl)imidazol-1-yl]pentanoic acid; Birinapant analog; TL32711 analog; IAP Inhibitor; DIABLO mimetic; Apoptosis promoter 1
EINECS	Contact for details

Quality Control

Our Smac Inhibitor 1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing identity, purity, and strength is provided with every shipment to ensure compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.