Description

Lorcaserin-L-Tartrate (2:1) is a high-purity, non-racemic salt form of the selective serotonin 2C receptor agonist, lorcaserin. This specific 2:1 stoichiometric ratio with L-tartaric acid is critical for ensuring optimal pharmaceutical activity, stability, and bioavailability. It is an essential advanced pharmaceutical intermediate primarily required by research institutions and manufacturers developing and producing innovative therapeutic agents for weight management and related metabolic disorders.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of prescription weight management medications.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of drug products.
• Clinical Research Material: Serves as a key material in preclinical and clinical studies investigating mechanisms of appetite suppression and metabolic regulation.
• Process Development: Utilized in scaling up and optimizing synthetic routes for commercial API manufacturing.
• Regulatory Submissions: Supplied as a characterized substance for inclusion in Drug Master Files (DMF) and regulatory dossiers (e.g., for FDA, EMA).

Basic Information

Product Name	Lorcaserin-L-Tartrate (2:1)
CAS No.	847063-12-1
Molecular Formula	C22H30ClN2O8
Molecular Weight	485.94 g/mol
Synonyms	Lorcaserin L-Tartrate; Lorcaserin Hemitartrate; (1R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (2R,3R)-2,3-dihydroxybutanedioate (2:1); APD-356; Belviq (as the active ingredient); (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (2R,3R)-2,3-dihydroxysuccinate (2:1)
EINECS	Contact for details

Quality Control

Our Lorcaserin-L-Tartrate (2:1) is manufactured under strict quality systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and potency, consistent with ICH guidelines for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing results for assay, chiral purity, related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Chiral Purity (HPLC)	≥ 99.0% (R-enantiomer)
Related Substances (HPLC)	Individual unknown impurity: ≤ 0.10% Total impurities: ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.