Description

(S,S,R,S)-Orlistat CAS NO 130193-42-9 is a specific stereoisomer of the active pharmaceutical ingredient used as a potent gastrointestinal lipase inhibitor. This compound is critical for pharmaceutical research and development, particularly in the study of anti-obesity drug mechanisms and the synthesis of advanced therapeutic agents. It is primarily required by pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in metabolic disorder therapeutics.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a key intermediate or reference standard in the production of lipase inhibitor-based pharmaceuticals.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies to investigate the efficacy, pharmacokinetics, and metabolism of anti-obesity drugs.
• Reference Standard for Analytical Testing: Employed in quality control laboratories for method development, validation, and impurity profiling via HPLC, LC-MS, or NMR.
• Metabolic Disorder Studies: A vital tool in academic and industrial research focusing on lipid absorption, pancreatic function, and obesity-related pathways.
• Process Chemistry Development: Utilized for optimizing synthetic routes, scaling up production, and ensuring stereochemical purity in API manufacturing.
• Formulation Development: Aids in the development of stable and bioavailable dosage forms, such as capsules or tablets.

Basic Information

Product Name	(S,S,R,S)-Orlistat
CAS No.	130193-42-9
Molecular Formula	C29H53NO5
Molecular Weight	495.74 g/mol
Synonyms	Tetrahydrolipstatin (THL); Orlistat isomer; (2S)-1-[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl-dodecyl (2S)-2-formamido-4-methyl-pentanoate; Lipase inhibitor; Xenical isomer; RO 18-0647/007; (S,S,R,S)-Tetrahydrolipstatin
EINECS	Contact for details

Quality Control

Our (S,S,R,S)-Orlistat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (S,S,R,S)-isomer
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.