Description

(S,R,R,R)-Orlistat CAS NO 111466-61-6 is a specific stereoisomer of the active pharmaceutical ingredient Orlistat, a potent and selective inhibitor of gastrointestinal lipases. This high-purity intermediate is critical for the research and development of advanced pharmaceutical formulations targeting obesity and related metabolic disorders. It is essential for pharmaceutical manufacturers, research institutions, and fine chemical suppliers focused on producing or investigating next-generation lipase inhibitors with precise stereochemical control.

Application

• Pharmaceutical Intermediate: Primary use as a key chiral building block in the synthesis of active pharmaceutical ingredients (APIs) for anti-obesity drugs.
• Metabolic Disorder Research: A critical reference standard and tool compound in biochemical and pharmacological studies of lipase function and fat absorption.
• Process Development: Used in the development and optimization of stereoselective synthetic routes for complex pharmaceutical molecules.
• Analytical Standard: Serves as a high-purity standard for quality control (QC) and analytical method development (e.g., HPLC, chiral analysis) in pharmaceutical labs.
• Formulation Studies: Employed in pre-formulation research to study the physicochemical properties and stability of lipase inhibitor-based formulations.

Basic Information

Product Name	(S,R,R,R)-Orlistat
CAS No.	111466-61-6
Molecular Formula	C29H53NO5
Molecular Weight	495.74 g/mol
Synonyms	(S)-Orlistat; Tetrahydrolipstatin (S,R,R,R)-isomer; N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester; (S)-Tetrahydrolipstatin; Lipase inhibitor (S,R,R,R)-isomer; Orlistat Stereoisomer; (S,R,R,R)-Tetrahydrolipstatin; (S)-THL
EINECS	Contact for details

Quality Control

Our (S,R,R,R)-Orlistat is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.