Description

(S,S,R,R)-Orlistat CAS NO 111466-62-7 is a specific stereoisomer of the active pharmaceutical ingredient Orlistat, a potent and selective inhibitor of gastrointestinal lipases. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the synthesis of advanced drug candidates targeting obesity and metabolic disorders. It is essential for manufacturers and research institutions requiring precise stereochemical control for efficacy and safety studies.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of Orlistat and its structural analogs.
• Active Pharmaceutical Ingredient (API) Research: Used in preclinical and clinical research for developing novel lipase inhibitor therapies.
• Metabolic Disorder Studies: A vital tool for biochemical research into lipid absorption, obesity, and related metabolic pathways.
• Process Chemistry & Scale-up: Serves as a reference standard and starting material for process optimization and analytical method development.
• Quality Control & Regulatory Submissions: Employed as a high-purity reference standard for assay validation and regulatory filing support.

Basic Information

Product Name	(S,S,R,R)-Orlistat
CAS No.	111466-62-7
Molecular Formula	C29H53NO5
Molecular Weight	495.74 g/mol
Synonyms	(S,S,R,R)-Tetrahydrolipstatin; (3S,4S,5R,6R)-4-[(2S,3S)-3-Hexyl-4-oxooxetan-2-yl]oxy-3,5-dihydroxy-6-[(1S)-1-hydroxytridecyl]oxane-2-carboxylic acid; (S,S,R,R)-THL; Orlistat Stereoisomer; Lipase Inhibitor Intermediate; Xenical Intermediate (S,S,R,R-form)
EINECS	Contact for details

Quality Control

Our (S,S,R,R)-Orlistat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S,S,R,R-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.