Description

Tesofensine is a potent and selective triple monoamine reuptake inhibitor (TRI) that has been extensively studied for its therapeutic potential. This compound is significant for its unique pharmacological profile, targeting key neurotransmitters involved in appetite regulation and mood. It is primarily required by pharmaceutical research and development organizations, contract research organizations (CROs), and academic institutions focused on developing novel treatments for metabolic disorders and central nervous system conditions.

Application

• Pharmaceutical R&D: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel anti-obesity and weight management therapies.
• Preclinical Research: Used in in vitro and in vivo studies to investigate the mechanisms of monoamine reuptake inhibition and its effects on energy homeostasis and behavior.
• Metabolic Disorder Studies: Applied in research models to evaluate efficacy in reducing food intake, promoting weight loss, and improving metabolic parameters.
• Neuroscience Research: Utilized as a tool compound to study the role of serotonin, noradrenaline, and dopamine reuptake in various CNS pathways and disorders.
• Analytical Method Development: Acts as a high-purity standard for developing and validating HPLC, LC-MS, and other analytical methods in quality control laboratories.
• Process Chemistry: Employed as a critical intermediate for the synthesis and scale-up of advanced pharmaceutical candidates targeting the central nervous system.

Basic Information

Product Name	Tesofensine
CAS No.	195875-84-4
Molecular Formula	C17H23ClN2O
Molecular Weight	306.83 g/mol
Synonyms	(1R,2S,3S,5S)-3-(3,4-Dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxamide; NS 2330; (1R,2S,3S,5S)-3-(3,4-Dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid amide; 8-Methyl-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]octane-2-carboxamide
EINECS	Contact for details

Quality Control

Our Tesofensine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing results from tests including assay, related substances, residual solvents, and heavy metals. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.