Description

(S,R,S,S)-Orlistat is a specific stereoisomer of the active pharmaceutical ingredient used as a potent gastrointestinal lipase inhibitor. This compound is critical for pharmaceutical research and development, particularly in the study of anti-obesity drug mechanisms and the synthesis of advanced therapeutic agents. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in metabolic disorder research and high-purity active pharmaceutical ingredient (API) production.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of Orlistat and related lipase inhibitor APIs.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical labs.
• Metabolic Research: A vital tool for in-vitro and in-vivo studies investigating pancreatic lipase inhibition, fat absorption, and obesity treatment pathways.
• Process Chemistry: Employed in route scouting and optimization for the commercial-scale manufacturing of anti-obesity medications.
• Impurity Profiling: Serves as a stereoisomeric impurity standard to ensure the purity and safety profile of the final drug substance.
• Academic Research: Utilized in university and institutional research for pharmacological and biochemical studies.

Basic Information

Product Name	(S,R,S,S)-Orlistat
CAS No.	111466-63-8
Molecular Formula	C29H53NO5
Molecular Weight	495.74 g/mol
Synonyms	(S)-Form N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-Hexyl-4-oxo-2-oxetanyl]methyl]dodecyl Ester; Tetrahydrolipstatin Stereoisomer; (S,R,S,S)-Tetrahydrolipstatin; Orlistat Impurity; Lipase Inhibitor SRS; THL Stereoisomer
EINECS	Contact for details

Quality Control

Our (S,R,S,S)-Orlistat is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and chiral methods for stereochemical confirmation, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (by Chiral HPLC)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.