Description

1-Difluoromethyl-2,4-Difluorobenzene is a high-value fluorinated aromatic building block, distinguished by its unique difluoromethyl substituent. This compound is essential for introducing fluorine atoms into complex molecular architectures, a critical step in modern pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the life sciences sector for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for constructing bioactive molecules, particularly in the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics where fluorine substitution modulates potency, metabolic stability, and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance biological activity and environmental persistence profiles.
• Material Science Precursor: Serves as a monomer or building block for synthesizing specialty polymers, liquid crystals, and organic electronic materials that require fluorinated aromatic units for specific electronic or surface properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution reactions to introduce fluorinated benzyl motifs into complex organic frameworks.

Basic Information

Product Name	1-Difluoromethyl-2,4-Difluorobenzene
CAS No.	845866-84-4
Molecular Formula	C7H4F4
Molecular Weight	164.10 g/mol
Synonyms	2,4-Difluoro-1-(difluoromethyl)benzene; α,α,2,4-Tetrafluorotoluene; 2,4-Difluorobenzylidene Difluoride; (Difluoromethyl)-2,4-difluorobenzene; Benzene, 1-(difluoromethyl)-2,4-difluoro-; 2,4-Difluoro-α,α-difluorotoluene
EINECS	Contact for details

Quality Control

Our 1-Difluoromethyl-2,4-Difluorobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.