Description

1-Bromo-2-Difluoromethylbenzene is a versatile halogenated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the strategic placement of bromine and difluoromethyl groups on the benzene ring, enabling selective functionalization and the introduction of fluorine atoms, which are critical for modulating the properties of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing the difluoromethyl moiety to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Material Science: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig couplings to form complex biaryl structures.
• Fluorine Chemistry Research: An essential reagent for academic and industrial research focused on organofluorine chemistry and the development of new fluorination methodologies.
• Ligand and Catalyst Development: Utilized to synthesize novel phosphine or nitrogen-based ligands for asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	1-Bromo-2-Difluoromethylbenzene
CAS No.	845866-82-2
Molecular Formula	C7H5BrF2
Molecular Weight	207.02 g/mol
Synonyms	2-Bromobenzyl Difluoride; o-Bromobenzyl Difluoride; (2-Bromophenyl)difluoromethane; 2-Bromo-α,α-difluorotoluene; 1-Bromo-2-(difluoromethyl)benzene; 2-Bromobenzal Difluoride; Benzene, 1-bromo-2-(difluoromethyl)-
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Difluoromethylbenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 2°C and 8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.