Description

2-Bromo-1-Difluoromethyl-4-Fluorobenzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound is valued for its unique substitution pattern, which allows for selective functionalization and the introduction of difluoromethyl and fluorine groups into target molecules. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing difluoromethyl motifs which can improve metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the fluorine and bromine atoms are crucial for activity and selectivity.
• Material Science Research: Serves as a precursor for liquid crystals, organic semiconductors, and other specialty fluorinated materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Fluorine Chemistry Exploration: An important reagent for studying the effects of fluorine and difluoromethyl groups on aromatic systems in medicinal and materials chemistry.

Basic Information

Product Name	2-Bromo-1-Difluoromethyl-4-Fluorobenzene
CAS No.	845866-81-1
Molecular Formula	C7H4BrF3
Molecular Weight	225.01 g/mol
Synonyms	1-Bromo-2-difluoromethyl-5-fluorobenzene; 2-Difluoromethyl-4-fluorobromobenzene; 4-Fluoro-2-(difluoromethyl)bromobenzene; 2-Bromo-α,α-difluoro-4-fluorotoluene; Benzene, 2-bromo-1-(difluoromethyl)-4-fluoro-; 845866-81-1
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-1-Difluoromethyl-4-Fluorobenzene is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting R&D and process chemistry standards. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container should be kept tightly sealed to prevent moisture ingress and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.