Description

Sc-558 CAS NO 845674-84-2 is a high-purity chemical compound widely recognized for its role as a selective and potent inhibitor of the cyclooxygenase-2 (COX-2) enzyme. This specificity makes it a valuable research tool for studying inflammatory pathways, pain mechanisms, and related biochemical processes. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in drug discovery and development.

Application

• Biochemical Research: A key tool for investigating the role of COX-2 in inflammation, pain, and fever pathways in vitro and in vivo.
• Drug Discovery: Used as a reference standard and lead compound in the development of novel non-steroidal anti-inflammatory drugs (NSAIDs) and analgesic agents.
• Pharmacological Studies: Employed to elucidate enzyme kinetics, inhibitor binding, and selectivity profiles against COX-1 and other related enzymes.
• Cell Signaling Research: Applied in studies of prostaglandin biosynthesis and its downstream effects on cellular processes.
• Academic & Institutional Research: Serves as a critical reagent for graduate and post-doctoral research projects in medicinal chemistry and pharmacology.

Basic Information

Product Name	Sc-558
CAS No.	845674-84-2
Molecular Formula	C16H14N2O3S
Molecular Weight	314.36 g/mol
Synonyms	SC-558; 4-[5-(4-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide; COX-2 Inhibitor SC-558; Celecoxib Derivative; Selective COX-2 Inhibitor; 1H-Pyrazole-1-benzenesulfonamide derivative
EINECS	Contact for details

Quality Control

Our Sc-558 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. All materials are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards to support the integrity of your scientific work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.