Description

Ifn α-Ifnar-In-1 is a potent and selective small molecule inhibitor of the interferon alpha/beta receptor (IFNAR). This compound matters as a critical research tool for dissecting the Type I interferon signaling pathway, which is central to immunology, virology, and oncology studies. It is needed by pharmaceutical R&D teams and academic researchers focused on autoimmune diseases, antiviral responses, and cancer immunotherapy development.

Application

• Biochemical Research: Used as a selective antagonist to inhibit IFNAR1 signaling in cell-based assays and mechanistic studies.
• Immunology Studies: Essential for investigating the role of Type I interferon in autoimmune conditions like systemic lupus erythematosus (SLE).
• Virology Research: Employed to block the host's interferon-mediated antiviral defense, allowing study of viral pathogenesis and replication.
• Oncology Research: Applied in cancer research to understand how tumor cells evade immune surveillance via interferon pathways.
• Drug Discovery: Serves as a reference compound or positive control in high-throughput screening for novel IFNAR inhibitors.
• Signal Transduction Analysis: A key reagent for mapping downstream JAK-STAT signaling events triggered by interferon binding.

Basic Information

Product Name	Ifn α-Ifnar-In-1
CAS No.	844882-93-5
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	IFNAR Inhibitor II; IFN-α/β Receptor Inhibitor; 6-[[4-(4-Methyl-1-piperazinyl)phenyl]amino]-N,7-dihydro-4-methyl-7-oxothieno[2,3-b]pyridine-5-carboxamide; 6-({4-[4-Methylpiperazin-1-yl]phenyl}amino)-4-methyl-7-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide; TTI-101 (developmental code name); IFNAR1 antagonist
EINECS	Contact for details

Quality Control

Our Ifn α-Ifnar-In-1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for research use. Certificates of Analysis (COA) with detailed chromatograms and spectral data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.