Description

Akt Kinase Inhibitor CAS NO 842148-40-7 is a potent and selective small molecule inhibitor of the Akt (Protein Kinase B) signaling pathway. This compound is a critical research tool for studying cellular processes such as proliferation, survival, and metabolism, with significant implications in oncology and metabolic disease research. It is essential for pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in target validation, high-throughput screening, and preclinical drug development.

Application

• Biochemical Research: Used as a selective inhibitor to study the role of Akt isoforms (Akt1, Akt2, Akt3) in signal transduction pathways.
• Oncology Research: A key tool for investigating tumor cell survival, growth, and resistance mechanisms, supporting the development of novel cancer therapeutics.
• Cell-Based Assays: Employed in high-content screening (HCS) and phenotypic screening to evaluate compound efficacy and cellular responses.
• Target Validation: Facilitates the functional analysis of the PI3K/Akt/mTOR pathway in various disease models.
• Preclinical Development: Serves as a reference standard or pharmacologic probe in in vitro and in vivo studies for drug candidate evaluation.
• Metabolic Disease Studies: Applied in research exploring insulin signaling, glucose metabolism, and related disorders.

Basic Information

Product Name	Akt Kinase Inhibitor
CAS No.	842148-40-7
Molecular Formula	C₂₀H₂₅N₅O₃
Molecular Weight	383.45 g/mol
Synonyms	MK-2206; Akt Inhibitor VIII; Akt1/2 Inhibitor; 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one; 8-(4-(1-Aminocyclobutyl)phenyl)-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one
EINECS	Contact for details

Quality Control

Our Akt Kinase Inhibitor is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and must be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.