Description

1-Acetyl-2-Methylindoline-5-Sulphonyl Chloride is a specialized sulfonyl chloride derivative, a key reactive intermediate in modern synthetic chemistry. Its primary value lies in its role as a versatile building block for constructing more complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require a high-purity, reliable reagent for sulfonamide and sulfonate formation.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the sulfonyl moiety imparts specific biological activity.
• Functional Material Research: Serves as a monomer or modifying agent in the creation of specialty polymers, dyes, and photoactive materials.
• Chemical Biology & Proteomics: Acts as a reactive handle for labeling, cross-linking, or modifying biomolecules in research applications.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing client-specific target molecules.

Basic Information

Product Name	1-Acetyl-2-Methylindoline-5-Sulphonyl Chloride
CAS No.	841275-78-3
Molecular Formula	C12H12ClNO3S
Molecular Weight	285.75 g/mol
Synonyms	1-Acetyl-2-methyl-2,3-dihydro-1H-indole-5-sulfonyl chloride; 2-Methyl-1-acetylindoline-5-sulfonyl chloride; 5-(Chlorosulfonyl)-1-acetyl-2-methylindoline; 1H-Indole-5-sulfonyl chloride, 1-acetyl-2,3-dihydro-2-methyl-; AMISCl; 841275-78-3
EINECS	Contact for details

Quality Control

Our 1-Acetyl-2-Methylindoline-5-Sulphonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.