Description

Sirt1 Activator 3 CAS NO 839699-72-8 is a potent and selective small-molecule activator of the Sirtuin 1 (SIRT1) enzyme, a key regulator of cellular metabolism, stress response, and aging pathways. This compound is of significant interest for research into metabolic disorders, neurodegenerative diseases, and longevity. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics and understanding sirtuin biology.

Application

• Biochemical Research: Used as a critical tool compound to study SIRT1 deacetylase activity, its downstream signaling pathways, and its role in cellular homeostasis.
• Drug Discovery & Preclinical Studies: Serves as a lead molecule or reference standard in pharmaceutical R&D programs targeting age-related diseases, including type 2 diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD).
• Neurodegenerative Disease Research: Investigated in models of Alzheimer's, Parkinson's, and Huntington's disease to explore SIRT1's neuroprotective effects.
• Cardiovascular Research: Applied in studies examining SIRT1's role in endothelial function, vascular aging, and ischemic preconditioning.
• In Vitro & In Vivo Assays: Essential for validating assay systems, establishing dose-response curves, and benchmarking the activity of new SIRT1 modulator compounds.

Basic Information

Product Name	Sirt1 Activator 3
CAS No.	839699-72-8
Molecular Formula	C19H18N2O3S
Molecular Weight	354.42 g/mol
Synonyms	SRT 1720; SRT1720; 1,4-Dihydro-2,6-dimethyl-4-(2-trifluoromethylphenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester; N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)isonicotinamide; Sirtuin 1 Activator III; SIRT1 Activator, SRT1720
EINECS	Contact for details

Quality Control

Our Sirt1 Activator 3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing purity, assay results, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.