Description

2,4-Difluoro-3-Iodo-Pyridine is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing fluorinated and iodinated heterocycles.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of difluoro and iodo substituents.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Building block for organic electronic materials, such as those used in OLEDs and semiconductors, due to its electron-deficient pyridine core.
• Cross-Coupling Reactions: The iodine atom provides an excellent handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Negishi).
• Fluorination Chemistry Studies: Used as a model substrate in methodological development for further functionalization of fluorinated heteroarenes.

Basic Information

Item	Details
Product Name	2,4-Difluoro-3-Iodo-Pyridine
CAS No.	837364-88-2
Molecular Formula	C5H2F2IN
Molecular Weight	256.98 g/mol
Synonyms	3-Iodo-2,4-difluoropyridine; 2,4-Difluoro-3-iodopyridine; Pyridine, 2,4-difluoro-3-iodo-; 3-Iodo-2,4-difluoropyridine; 837364-88-2 (CAS); 2,4-Difluoro-3-iodo-pyridine
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-3-Iodo-Pyridine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality system supports development and cGMP manufacturing requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/GC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.