Description

Desmethyl Gabazine is a high-purity chemical reference standard and research compound with the CAS registry number 835870-49-0. This compound is a key intermediate and a selective pharmacological tool used in advanced neuroscience and pharmaceutical research. It is primarily required by research institutions, pharmaceutical R&D laboratories, and chemical manufacturers focused on developing and analyzing neuroactive substances, particularly GABA receptor antagonists.

Application

• Neuroscience Research: Used as a potent and selective antagonist for GABAA receptor studies, aiding in the understanding of inhibitory neurotransmission.
• Pharmaceutical R&D: Serves as a critical intermediate or reference standard in the development of novel neuropharmaceuticals and diagnostic agents.
• Biochemical Assays: Employed in high-throughput screening (HTS) and in vitro assays to investigate receptor-ligand interactions and mechanism of action.
• Metabolite Studies: Acts as a reference compound for the analysis of gabazine metabolism and related pharmacokinetic studies.
• Academic Research: Utilized in university and institutional labs for fundamental research on synaptic function and neurological disorders.
• Chemical Synthesis: Functions as a specialized building block for the synthesis of more complex, targeted research molecules.

Basic Information

Product Name	Desmethyl Gabazine
CAS No.	835870-49-0
Molecular Formula	C12H12N4O2
Molecular Weight	244.25 g/mol
Synonyms	6-Aminomethyl-3-hydroxy-2H-1,2,4-benzoxadiazine 1-oxide; 6-(Aminomethyl)-3-hydroxy-1,2,4-benzoxadiazine 1-oxide; SR-95531 Desmethyl; 2-(Carboxy-3-hydroxy-2H-1,2,4-benzoxadiazin-1-oxide) Desmethyl Derivative; Gabazine Impurity; GABAA Receptor Antagonist Intermediate
EINECS	Contact for details

Quality Control

Our Desmethyl Gabazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.