Description

(R)-20-Deoxy-20-Fluorocamptothecin CAS NO 828934-85-6 is a high-purity, fluorinated derivative of the potent topoisomerase I inhibitor, camptothecin. This compound is a critical advanced intermediate for the research and development of next-generation anticancer therapeutics, offering enhanced metabolic stability and targeted activity. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on oncology drug discovery and mechanism-of-action studies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel camptothecin-based anticancer agents.
• Oncology Research: Used as a reference standard and active compound in biochemical assays to study topoisomerase I inhibition.
• Drug Discovery & Development: Employed in structure-activity relationship (SAR) studies to optimize the potency and pharmacokinetic profile of chemotherapeutic candidates.
• Preclinical Studies: Utilized in in vitro and in vivo models to evaluate antitumor efficacy and toxicity profiles.
• Mechanistic Probe: Acts as a tool compound to investigate DNA damage and repair pathways in cancer cells.
• API Synthesis: A crucial precursor in the multi-step synthesis of potential active pharmaceutical ingredients (APIs) for clinical evaluation.

Basic Information

Product Name	(R)-20-Deoxy-20-Fluorocamptothecin
CAS No.	828934-85-6
Molecular Formula	C21H17FN2O4
Molecular Weight	380.37 g/mol
Synonyms	(R)-20-Fluoro-20-deoxycamptothecin; (20R)-20-Fluoro-20-deoxycamptothecin; 20-Fluoro-20-deoxycamptothecin, (R)-; 20-Deoxy-20-fluorocamptothecin; (R)-20-Fluoro-20-desoxycamptothecin; Camptothecin, 20-deoxy-20-fluoro-, (R)-; 828934-85-6
EINECS	Contact for details

Quality Control

Our (R)-20-Deoxy-20-Fluorocamptothecin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via NMR and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Certificates are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed under an inert atmosphere if specified and stored in a desiccator to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.