Description

S-(+)-Etomoxir is a high-purity, enantiomerically pure chemical compound used as a potent and selective inhibitor of carnitine palmitoyltransferase-1 (CPT-1). This compound matters for researchers and pharmaceutical developers because it is a critical tool for studying fatty acid oxidation and metabolic pathways, with significant implications in metabolic disease and oncology research. It is primarily needed by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in metabolic research, drug discovery, and the development of therapeutic agents targeting heart disease, diabetes, and cancer.

Application

• Metabolic Research Tool: Used as a selective inhibitor of mitochondrial CPT-1 to study fatty acid β-oxidation and its role in cellular energy metabolism.
• Cardiovascular Disease Research: Investigated in models of ischemic heart disease to understand the shift in myocardial substrate utilization.
• Oncology and Cancer Metabolism: Employed in research to explore the dependency of certain cancer cells on fatty acid oxidation for growth and survival.
• Diabetes and Insulin Resistance Studies: Applied in preclinical research to modulate glucose and lipid metabolism pathways.
• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in API manufacturing.
• Biochemical Assay Development: Used in the development and validation of in vitro enzymatic assays targeting the CPT-1 enzyme complex.

Basic Information

Product Name	S-(+)-Etomoxir
CAS No.	828934-40-3
Molecular Formula	C15H19NO3
Molecular Weight	261.32 g/mol
Synonyms	(S)-Etomoxir; (S)-(+)-Etomoxir; (2S)-2-[6-(4-Chlorophenoxy)hexyl]oxirane-2-carboxylic acid; (S)-2-[6-(4-Chlorophenoxy)hexyl]glycidic acid; (S)-Etomoxir free acid; CPT-1 Inhibitor (S)-enantiomer; Sodium-(S)-Etomoxir (salt form precursor)
EINECS	Contact for details

Quality Control

Our S-(+)-Etomoxir is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and purity meet exacting standards for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, confirming compliance with specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-enantiomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.