Description

4-Fluoro-2-(Methylsulfonyl)Toluene is a high-value fluorinated aromatic sulfone building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique substitution pattern enables precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce both fluorine and methylsulfonyl functionalities into complex molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging the bioactivity of the fluorinated sulfone moiety.
• Material Science Research: Serves as a monomer or precursor for specialty polymers and advanced materials with tailored electronic or surface properties.
• Ligand and Catalyst Development: Employed in the creation of novel ligands for transition metal catalysis and organocatalysts.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes to study enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for client-specific synthesis projects requiring this specialized intermediate.

Basic Information

Product Name	4-Fluoro-2-(Methylsulfonyl)Toluene
CAS No.	828270-66-2
Molecular Formula	C8H9FO2S
Molecular Weight	188.22 g/mol
Synonyms	1-Fluoro-4-methyl-2-(methylsulfonyl)benzene; 2-Methylsulfonyl-4-fluorotoluene; 4-Fluoro-2-methylsulfonyltoluene; 4-Fluoro-o-tolyl methyl sulfone; 2-(Methylsulfonyl)-4-fluorotoluene; 4-Fluoro-2-(methanesulfonyl)toluene; Benzene, 1-fluoro-4-methyl-2-(methylsulfonyl)-
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-(Methylsulfonyl)Toluene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.