Description

4-Fluoro-2-Methyl-1-(Methylsulphonyl)Benzene is a high-purity, specialized aromatic sulfone building block of significant importance in advanced organic synthesis. Its unique structure, featuring both fluorine and a methylsulfonyl group, makes it a critical intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for synthesizing specialized polymers, liquid crystals, or organic electronic materials due to its electron-withdrawing sulfone moiety.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems and mechanisms of action.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Fluoro-2-Methyl-1-(Methylsulphonyl)Benzene
CAS No.	828270-62-8
Molecular Formula	C8H9FO2S
Molecular Weight	188.22 g/mol
Synonyms	1-Fluoro-2-methyl-4-(methylsulfonyl)benzene; 4-Fluoro-2-methylphenyl methyl sulfone; 2-Methyl-4-fluorophenyl methyl sulfone; Methyl 4-fluoro-2-methylphenyl sulfone; 828270-62-8; 4-Fluoro-2-methyl-1-(methylsulfonyl)benzene; 1-Methylsulfonyl-4-fluoro-2-methylbenzene
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-2-Methyl-1-(Methylsulphonyl)Benzene is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high standards required for research and process chemistry. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines where applicable for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.