Description

2-Fluoro-6-(Methylsulfonyl)Toluene is a high-value fluorinated aromatic sulfone building block, essential for advanced organic synthesis. Its unique structure, featuring both a fluorine atom and a methylsulfonyl group on the toluene backbone, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluorine and sulfone motifs.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive halogen and sulfone groups.
• Ligand and Catalyst Development: Utilized in the design of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Acts as a core structure for developing molecular probes and tags used in biochemical and diagnostic research.

Basic Information

Product Name	2-Fluoro-6-(Methylsulfonyl)Toluene
CAS No.	828270-59-3
Molecular Formula	C8H9FO2S
Molecular Weight	188.22 g/mol
Synonyms	1-Fluoro-2-methyl-3-(methylsulfonyl)benzene; 2-Methyl-3-(methylsulfonyl)fluorobenzene; 3-Fluoro-2-methylphenyl methyl sulfone; 2-Fluoro-6-methylsulfonyltoluene; 6-Fluoro-2-methylphenyl methyl sulfone; Toluene, 2-fluoro-6-(methylsulfonyl)-; α,2-Difluoro-6-(methylsulfonyl)toluene (incorrect but common search variant); 828270-59-3
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-6-(Methylsulfonyl)Toluene is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We provide full traceability and guarantee high purity and lot-to-lot consistency critical for research and scale-up processes. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles by HPLC, GC, NMR, and IR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.