Description

Danusertib is a potent and selective Aurora kinase inhibitor, a class of compounds critical for regulating cell division. This small molecule is a valuable research tool and development candidate for investigating novel cancer therapeutics. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology. The compound is supplied as a high-purity reference standard to support drug discovery and preclinical studies.

Application

• Oncology Research: Used as a key pharmacological tool to study the role of Aurora kinases (A, B, and C) in tumor cell proliferation and survival.
• Drug Discovery & Development: Serves as a reference compound or lead molecule in the development of novel anti-cancer agents targeting mitotic pathways.
• Biochemical Assays: Employed in in vitro kinase inhibition assays to evaluate potency and selectivity profiles.
• Cellular Mechanism Studies: Applied in cell-based studies to investigate the effects of Aurora kinase inhibition on cell cycle arrest, apoptosis, and aneuploidy.
• Preclinical Modeling: Used in animal models of cancer to assess the efficacy and pharmacokinetics of Aurora kinase inhibition.
• Combination Therapy Research: Investigated for potential synergistic effects when used alongside other chemotherapeutic agents or targeted therapies.

Basic Information

Product Name	Danusertib
CAS No.	827318-97-8
Molecular Formula	C₂₇H₂₉N₅O₃
Molecular Weight	471.55 g/mol
Synonyms	PHA-739358; N-[5-[[5-(4-Methylpiperazin-1-yl)-1H-benzimidazol-2-yl]amino]-2-[(3S)-3-pyrrolidinyloxy]phenyl]furan-2-carboxamide; Danusertib dihydrochloride (salt form); Aurora Kinase Inhibitor III; UNII-8V4Y9FYM5T
EINECS	Contact for details

Quality Control

Our Danusertib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications. We support cGMP standards for advanced pharmaceutical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.