Description

Jwh 181 is a synthetic cannabinoid receptor agonist of significant interest in pharmacological research. This compound is a valuable tool for scientists studying the endocannabinoid system and its complex interactions within biological pathways. It is primarily utilized in preclinical research and analytical reference applications within the pharmaceutical and life sciences sectors. The product is supplied under the identifier CAS No. 824960-03-4.

Application

• Pharmacological Research: Used as a reference standard and active agent in preclinical studies to investigate cannabinoid receptor (CB1/CB2) binding affinity, selectivity, and downstream signaling effects.
• Biochemical Assay Development: Serves as a key ligand in the development and validation of high-throughput screening (HTS) assays for drug discovery programs targeting the endocannabinoid system.
• Metabolic Pathway Analysis: Employed in studies to understand the metabolic fate and pharmacokinetic profiles of synthetic cannabinoids.
• Analytical Reference Standard: Essential for the calibration of analytical equipment (HPLC, GC-MS, LC-MS) and for use as a certified reference material (CRM) in forensic and clinical toxicology laboratories.
• Structure-Activity Relationship (SAR) Studies: Provides a core chemical scaffold for medicinal chemists to design and synthesize novel analogs to explore therapeutic potential.

Basic Information

Product Name	Jwh 181
CAS No.	824960-03-4
Molecular Formula	C24H23NO
Molecular Weight	341.45 g/mol
Synonyms	1-Pentyl-3-(1-naphthoyl)indole; JWH-181; 1-Pentyl-1H-indol-3-yl-(1-naphthyl)methanone; (1-Pentyl-1H-indol-3-yl)-1-naphthalenyl-methanone; Naphthalen-1-yl(1-pentyl-1H-indol-3-yl)methanone; JWH 181; JWH181
EINECS	Contact for details

Quality Control

Every batch of Jwh 181 is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.