Description

Stat3 Inhibitor Ix, Cpd188 is a potent and selective cell-permeable inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3) signaling pathway. This compound is a critical research tool for investigating the role of STAT3 in oncogenesis, immune response, and inflammatory diseases. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in cancer biology, immunology, and drug discovery programs. The product is supplied under the Calbiochem brand, ensuring high standards of quality and reliability for scientific research.

Application

• Cancer Research: Used to study the role of STAT3 in tumor cell proliferation, survival, and metastasis in various cancer models.
• Drug Discovery: Serves as a reference compound and pharmacological tool for screening and validating novel STAT3 pathway inhibitors.
• Immunology Studies: Employed to dissect STAT3-mediated signaling in immune cell differentiation and function, including T-helper 17 (Th17) cells.
• Inflammatory Disease Models: Applied in research on autoimmune and chronic inflammatory conditions where STAT3 is a key regulatory node.
• Biochemical Assays: Used in vitro to characterize enzyme kinetics and inhibition constants for STAT3 and related proteins.
• Cell Signaling Pathway Analysis: A key reagent for elucidating crosstalk between the STAT3, JAK, and other oncogenic signaling pathways.

Basic Information

Item	Details
Product Name	Stat3 Inhibitor Ix, Cpd188
CAS No.	823828-18-8
Molecular Formula	C₂₀H₁₅N₃O₃S
Molecular Weight	377.42 g/mol
Synonyms	STAT3 Inhibitor IX; Cpd188; Calbiochem 573102; 5-[(4-Methylphenyl)sulfonyl]-2-(1H-pyrrol-1-yl)benzonitrile; NSC 74859; S3I-201; STAT3 Inhibitor, S3I-201; STAT3 Inhibitor VII
EINECS	Contact for details

Quality Control

Our Stat3 Inhibitor Ix, Cpd188 is manufactured and tested to meet the stringent requirements of research-grade biochemicals. Each lot undergoes comprehensive analytical characterization, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A Certificate of Analysis (COA) detailing batch-specific results is provided to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C under desiccant. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.