Description

5-Thiazolecarboxylicacid,4-(Difluoromethyl)-2-Methyl-,Ethylester(9Ci) is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound matters for its unique molecular architecture, incorporating a difluoromethyl group and a thiazole core, which are critical motifs for modulating the physicochemical and biological properties of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, particularly in medicinal chemistry for drug discovery programs. Its ester functionality offers a versatile handle for further synthetic elaboration.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, infectious diseases, and metabolic conditions.
• Agrochemical Synthesis: Serves as a crucial building block for developing next-generation herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance bioavailability and environmental stability.
• Material Science Research: Used in the synthesis of specialized ligands, catalysts, and organic electronic materials due to the electron-deficient nature of the thiazole ring.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological processes and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	5-Thiazolecarboxylicacid,4-(Difluoromethyl)-2-Methyl-,Ethylester(9Ci)
CAS No.	823234-82-8
Molecular Formula	C8H9F2NO2S
Molecular Weight	221.22 g/mol
Synonyms	Ethyl 4-(Difluoromethyl)-2-methyl-1,3-thiazole-5-carboxylate; 4-(Difluoromethyl)-2-methyl-1,3-thiazole-5-carboxylic Acid Ethyl Ester; 1,3-Thiazole-5-carboxylic acid, 4-(difluoromethyl)-2-methyl-, ethyl ester; 5-Thiazolecarboxylic acid, 4-(difluoromethyl)-2-methyl-, ethyl ester (9CI); 823234-82-8; Ethyl 4-(difluoromethyl)-2-methylthiazole-5-carboxylate
EINECS	Contact for details

Quality Control

Our 5-Thiazolecarboxylicacid,4-(Difluoromethyl)-2-Methyl-,Ethylester(9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP principles and adherence to ISO standards ensure a reliable supply of this high-purity intermediate for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions or inert atmosphere to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.