Description

1-[3-(Trifluoromethyl)Pyridin-2-Yl]Piperidine-4-Carboxylic Acid is a high-value, multi-functional heterocyclic building block featuring a piperidine core substituted with a carboxylic acid group and a trifluoromethylpyridine moiety. This compound is critical for medicinal chemistry and advanced material science due to its unique structural features that enable precise modulation of biological activity and physicochemical properties. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the trifluoromethyl group enhances lipophilicity and biological stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Incorporated into the design of specialty polymers and organic electronic materials to modify solubility and electronic characteristics.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and protein interactions.

Basic Information

Product Name	1-[3-(Trifluoromethyl)Pyridin-2-Yl]Piperidine-4-Carboxylic Acid
CAS No.	821768-09-6
Molecular Formula	C12H13F3N2O2
Molecular Weight	274.24 g/mol
Synonyms	Piperidine-4-carboxylic acid, 1-[3-(trifluoromethyl)-2-pyridinyl]-; 1-(3-(Trifluoromethyl)pyridin-2-yl)piperidine-4-carboxylic acid; 4-Piperidinecarboxylic acid, 1-[3-(trifluoromethyl)-2-pyridinyl]-; 821768-09-6; 1-(3-Trifluoromethyl-2-pyridyl)piperidine-4-carboxylic acid; 1-(3-(Trifluoromethyl)pyridin-2-yl)piperidine-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 1-[3-(Trifluoromethyl)Pyridin-2-Yl]Piperidine-4-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability. Every lot is subjected to comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.