Description

Glutathione-(Glycine-13C2,15N1) is a stable isotope-labeled analog of the essential tripeptide antioxidant glutathione, specifically labeled on the glycine moiety. This compound is a critical tool for quantitative proteomic and metabolic research, enabling precise tracking and measurement of glutathione metabolism and redox status in biological systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced life science sectors for applications in mass spectrometry, tracer studies, and the development of diagnostic assays.

Application

• Internal Standard for LC-MS/MS Quantification: Serves as a crucial reference standard for the accurate mass spectrometric analysis of endogenous glutathione levels in complex biological matrices like plasma, tissues, and cell lysates.
• Metabolic Flux Analysis (MFA): Used as a tracer to study the dynamics of glutathione synthesis, turnover, and utilization in cellular pathways, providing insights into oxidative stress mechanisms.
• Drug Metabolism and Pharmacokinetics (DMPK): Employed in studies to investigate drug-induced changes in glutathione conjugation and redox homeostasis.
• Biomarker Discovery and Validation: Facilitates the development and validation of clinical assays measuring glutathione-related biomarkers for diseases involving oxidative stress.
• Nutritional and Clinical Research: Applied in studies examining the impact of diet, supplements, or disease states on glutathione metabolism.
• Synthesis of Labeled Conjugates: Acts as a building block for synthesizing more complex isotope-labeled metabolites or drug conjugates for advanced research applications.

Basic Information

Product Name	Glutathione-(Glycine-13C2,15N1)
CAS No.	815610-65-2
Molecular Formula	C1013C2H17N315NO6S
Molecular Weight	310.29 g/mol (for labeled form)
Synonyms	L-Glutathione (glycine-13C2,15N); γ-L-Glutamyl-L-cysteinyl-glycine (glycine-13C2,15N); GSH (13C2,15N-Gly); (2S)-2-Amino-4-{[(1R)-1-[(carboxymethyl-13C2,15N)carbamoyl]-2-sulfanylethyl]carbamoyl}butanoic acid; Isotopically Labeled Glutathione; Stable Isotope-Labeled Glutathione; 13C2,15N-Gly-Glutathione; Reduced Glutathione (Glycine-13C2,15N1)
EINECS	Contact for details

Quality Control

Every batch of Glutathione-(Glycine-13C2,15N1) is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, specifying the assay, isotopic enrichment, and purity profile to ensure consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The product is hygroscopic and should be kept in a dry environment. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Enrichment	≥ 98 atom % 13C, ≥ 98 atom % 15N (on glycine moiety)
Assay (HPLC)	≥ 90%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.