Description

Casr Antagonist 18C is a potent and selective calcium-sensing receptor (CaSR) antagonist, a critical research tool in bone metabolism and endocrine studies. This compound is essential for investigating the role of CaSR in calcium homeostasis, parathyroid hormone secretion, and related physiological pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on metabolic bone disorders, hyperparathyroidism, and novel therapeutic development.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies of calcium-sensing receptor (CaSR) function and signaling.
• Drug Discovery & Development: Serves as a key intermediate or lead compound in the development of novel therapeutics for hyperparathyroidism and bone diseases.
• Biochemical Assays: Employed in high-throughput screening (HTS) and in vitro assays to evaluate CaSR antagonist activity and potency.
• Academic & Clinical Research: Facilitates fundamental research into calcium homeostasis, parathyroid gland physiology, and related endocrine disorders.
• Metabolic Disorder Studies: Applied in models studying the treatment of conditions related to abnormal calcium metabolism.

Basic Information

Product Name	Casr Antagonist 18C
CAS No.	802916-30-9
Molecular Formula	C₂₀H₂₀N₂O₃
Molecular Weight	336.39 g/mol
Synonyms	NPS 2143; (R)-N-(3-Methoxy-2-phenethyl)-2-(3-methoxyphenyl)ethanamine; Calcilytic NPS 2143; CaSR Antagonist NPS 2143; (R)-N-(3-Methoxy-2-phenethyl)-2-(3-methoxyphenyl)ethylamine; 18C CaSR Inhibitor; (R)-NPS 2143; 802916-30-9
EINECS	Contact for details

Quality Control

Our Casr Antagonist 18C is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.