Description

1,6,7,8-Indolizinetetrol, Octahydro-, (1R,6S,7R,8R,8Ar)- is a high-purity, stereochemically defined indolizine derivative, serving as a critical chiral building block and synthetic intermediate. Its value lies in its complex polyhydroxylated structure, which provides multiple points for selective functionalization, enabling the synthesis of sophisticated molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and complex natural product analogs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new therapeutic agents, including alkaloid-based drugs.
• Asymmetric Synthesis: Utilized as a sophisticated starting material or ligand precursor in catalytic asymmetric reactions to induce chirality.
• Natural Product Synthesis: Serves as a core structural unit in the total synthesis of complex indolizidine and related natural products.
• Biochemical Research: Used as a reference standard or probe in studying enzyme mechanisms and biological pathways involving polyol structures.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals requiring high stereochemical purity and specific functional group arrays.

Basic Information

Item	Detail
Product Name	1,6,7,8-Indolizinetetrol, Octahydro-, (1R,6S,7R,8R,8Ar)-
CAS No.	89955-60-2
Molecular Formula	C8H16O4
Molecular Weight	176.21 g/mol
Synonyms	(1R,6S,7R,8R,8aR)-Octahydro-1,6,7,8-indolizinetetrol; (1R,6S,7R,8R,8aR)-Octahydroindolizine-1,6,7,8-tetrol; 1,6,7,8-Tetrahydroxyoctahydroindolizine; DMDP (2,5-Dideoxy-2,5-imino-D-mannitol); Dihydroxymethyldihydroxypyrrolidine; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of 1,6,7,8-Indolizinetetrol, Octahydro-, (1R,6S,7R,8R,8Ar)- is produced under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to confirm stereochemical integrity and meet high-purity standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.