Description

2-(2,5-Dioxo-Pyrrolidin-1-Yl)-Ethanesulfonyl Chloride is a specialized, high-purity sulfonyl chloride derivative used as a key reactive intermediate in advanced organic synthesis. Its primary value lies in its ability to act as a versatile linker or activating agent, facilitating the introduction of sulfonate ester or sulfonamide functionalities into target molecules under controlled conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and bioconjugation sectors, particularly for developing active pharmaceutical ingredients (APIs), peptide synthesis, and creating functionalized polymers.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially in creating sulfonamide-based therapeutics.
• Peptide Modification & Bioconjugation: Used to selectively modify amino acid side chains (e.g., lysine, cysteine) or to attach labels, tags, or drug molecules to peptides, proteins, and antibodies.
• Polymer Chemistry: Serves as a functional monomer or cross-linking agent for producing specialty polymers with specific sulfonyl chloride-reactive sites.
• Agrochemical Synthesis: Employed in the research and development of new herbicides, fungicides, and insecticides that incorporate sulfonyl moieties.
• Material Science: Facilitates surface functionalization of materials for creating advanced coatings, sensors, or chromatographic media.
• Chemical Biology Probes: Acts as a reagent for developing activity-based probes (ABPs) to study enzyme function and mechanism.

Basic Information

Product Name	2-(2,5-Dioxo-Pyrrolidin-1-Yl)-Ethanesulfonyl Chloride
CAS No.	89756-66-1
Molecular Formula	C6H8ClNO4S
Molecular Weight	225.65 g/mol
Synonyms	1-(2-Chloroethanesulfonyl)-2,5-pyrrolidinedione; N-(2-Chloroethanesulfonyl)succinimide; Succinimidyl 2-Chloroethanesulfonate; 2,5-Dioxopyrrolidin-1-yl Ethanesulfonyl Chloride; 1-(Chloroethanesulfonyl)pyrrolidine-2,5-dione; NSC 339586; 2-(2,5-Dioxopyrrolidin-1-yl)ethanesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 2-(2,5-Dioxo-Pyrrolidin-1-Yl)-Ethanesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.