Description

Detirelix is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH) with potent antagonistic activity. This compound is a critical active pharmaceutical ingredient (API) and research tool for modulating the hypothalamic-pituitary-gonadal axis. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development of therapeutic agents for hormone-dependent conditions, including oncology and reproductive health.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of GnRH antagonist drugs for clinical use.
• Hormone-Dependent Cancer Research: Investigational tool for studying and developing treatments for prostate cancer, breast cancer, and endometriosis.
• Reproductive Medicine: Used in research related to fertility control, assisted reproduction, and the management of precocious puberty.
• Endocrinology Studies: Valuable reference standard and biochemical probe for investigating pituitary hormone secretion and receptor binding.
• Preclinical & Clinical Development: Serves as a key material in toxicology studies, pharmacokinetic profiling, and formulation development for new drug candidates.

Basic Information

Product Name	Detirelix
CAS No.	89662-30-6
Molecular Formula	C₈₀H₁₁₃ClN₁₈O₁₈
Molecular Weight	1683.3 g/mol
Synonyms	Detirelix Acetate; N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-Nδ-nicotinoyl-L-lysyl-Nδ-nicotinoyl-D-lysyl-L-leucyl-Nε-isopropyl-L-lysyl-L-prolyl-D-alaninamide; RS-68439; Antide; GnRH Antagonist (Detirelix); LHRH Antagonist (Detirelix)
EINECS	Contact for details

Quality Control

Our Detirelix is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and related substances, ensuring it meets high-grade pharmaceutical standards. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under controlled humidity conditions. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥97.0% (Total impurities ≤3.0%)
Single Unknown Impurity	≤1.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.