Description

11-Deoxy-13,14-Didehydro-16(S)-Methylprostaglandin E2 Methyl Ester is a synthetic prostaglandin analog, a key intermediate in the research and development of advanced pharmaceutical compounds. This high-purity chemical is valued for its precise stereochemistry and structural modifications, which are critical for studying biological pathways and developing novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on prostaglandin-based drug discovery and synthesis.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of novel prostaglandin-based drugs targeting inflammation, ocular pressure, and gastrointestinal disorders.
• Biochemical Research: Used as a reference standard and probe compound in pharmacological studies to investigate prostaglandin receptor (EP) activity and signal transduction mechanisms.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies, enabling the development of new chemical entities with optimized potency and selectivity.
• Process Development: Employed in scaling up synthetic routes and optimizing manufacturing processes for prostaglandin active pharmaceutical ingredients (APIs).
• Academic Synthesis: A valuable compound for teaching and research in advanced organic synthesis, particularly in stereoselective reactions and complex molecule construction.

Basic Information

Product Name	11-Deoxy-13,14-Didehydro-16(S)-Methylprostaglandin E2 Methyl Ester
CAS No.	89648-76-0
Molecular Formula	C22H34O5
Molecular Weight	378.51 g/mol
Synonyms	16(S)-Methyl-11-deoxy-13,14-didehydro-PGE2 methyl ester; Methyl 11-deoxy-13,14-didehydro-16-methylprostaglandin E2; 16-Methyl-11-deoxy-13,14-didehydro-PGE2 methyl ester; 11-Deoxy-13,14-didehydro-16-methyl-PGE2 methyl ester; 16(S)-Methyl-11-deoxy-13,14-didehydroprostaglandin E2 methyl ester; Prostaglandin E2 analog methyl ester; PGE2 derivative intermediate
EINECS	Contact for details

Quality Control

Our 11-Deoxy-13,14-Didehydro-16(S)-Methylprostaglandin E2 Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. For long-term storage, keep the primary container in a secondary, sealed vessel.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (16S isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.