Description

2-Chloro-5-Fluorobenzotrifluoride is a versatile fluorinated aromatic building block of significant commercial importance. Its unique structure, featuring both chloro and fluoro substituents on a trifluoromethylated benzene ring, makes it a critical intermediate in advanced chemical synthesis. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for constructing complex molecules. Its utility extends to materials science, where it serves as a precursor for specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in molecules requiring halogenated aromatic motifs for bioactivity or metabolic stability.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological activity.
• Liquid Crystal Materials: Serves as a core building block in the production of fluorinated liquid crystals for display technologies.
• Specialty Polymer Monomer: Employed in the synthesis of high-performance polymers with enhanced chemical resistance and thermal stability.
• Organic Synthesis Reagent: Utilized in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitution to introduce functionalized aryl groups.
• Chemical Research: A valuable compound for academic and industrial research in fluorochemistry and medicinal chemistry.

Basic Information

Product Name	2-Chloro-5-Fluorobenzotrifluoride
CAS No.	89634-75-3
Molecular Formula	C7H3ClF4
Molecular Weight	198.55 g/mol
Synonyms	1-Chloro-4-fluoro-2-(trifluoromethyl)benzene; 2-Chloro-α,α,α-trifluoro-5-fluorotoluene; 5-Fluoro-2-chlorobenzotrifluoride; 2-Chloro-5-fluorobenzylidene trifluoride; 2-Chloro-5-fluorophenyl trifluoromethane; 2-Chloro-5-fluoro-α,α,α-trifluorotoluene; 2-Chloro-5-fluoro-1-(trifluoromethyl)benzene; 2-Chloro-5-fluoro-1-(trifluoromethyl)benzene
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluorobenzotrifluoride is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistent performance. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting identity, assay, and impurity profiles. Our quality commitment supports compliance with cGMP and ISO standards where required for your application.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Density (at 20°C)	~1.45 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.