Description

Leukotriene B4-3-Aminopropylamide is a bioactive amide derivative of the potent pro-inflammatory lipid mediator Leukotriene B4 (LTB4). This compound is of significant value as a stable analog and research tool for studying LTB4 receptor signaling pathways and inflammatory responses. It is primarily needed by researchers and developers in the pharmaceutical, biotechnology, and life science research sectors for investigating inflammation, immune modulation, and related therapeutic targets.

Application

• Biochemical Research: Used as a stable analog of LTB4 to study its binding affinity, receptor activation (BLT1/BLT2), and downstream signaling cascades in cellular models of inflammation.
• Drug Discovery & Development: Serves as a critical reference standard and pharmacological tool in screening assays to identify and characterize novel anti-inflammatory compounds or LTB4 receptor antagonists.
• Immunology Studies: Applied in research to elucidate the role of leukotrienes in neutrophil chemotaxis, degranulation, and other immune cell functions.
• Inflammation Modeling: Utilized to induce and study inflammatory responses in in vitro and ex vivo experimental systems.
• Analytical Standard: Employed as a high-purity standard for the calibration of analytical equipment (e.g., HPLC, LC-MS) in quantitative bioanalysis.

Basic Information

Product Name	Leukotriene B4-3-Aminopropylamide
CAS No.	89596-43-0
Molecular Formula	C₂₇H₄₆N₂O₅
Molecular Weight	478.67 g/mol
Synonyms	LTB4-3-Aminopropylamide; Leukotriene B4 3-Aminopropyl Amide; 5(S),12(R)-Dihydroxy-6Z,8E,10E,14Z-eicosatetraenoyl-3-aminopropylamide; 3-Aminopropyl LTB4 amide; LTB4-APA; (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyicosa-6,8,10,14-tetraenoyl-3-aminopropylamide
EINECS	Contact for details

Quality Control

Our Leukotriene B4-3-Aminopropylamide is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis and structural confirmation. A detailed Certificate of Analysis (COA) is provided, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers should be sealed under vacuum or nitrogen after each use and allowed to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in ethanol, DMSO; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.