Description

Imirestat is a potent and selective aldose reductase inhibitor, a key compound in biochemical and pharmaceutical research. Its primary value lies in its ability to modulate polyol pathway activity, making it a critical tool for investigating diabetic complications, particularly neuropathy and retinopathy. This high-purity compound is essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors focused on metabolic disease research and novel therapeutic discovery.

Application

• Pharmaceutical R&D: Primary application as a reference standard and active pharmaceutical ingredient (API) intermediate in the development of therapeutics for diabetic complications.
• Biochemical Research: Used as a selective inhibitor to study the aldose reductase enzyme and the polyol pathway's role in cellular osmotic stress and oxidative damage.
• Preclinical Studies: Employed in animal models to investigate the efficacy and mechanisms of aldose reductase inhibition for preventing or treating diabetic neuropathy, cataracts, and nephropathy.
• Mechanistic Probes: Serves as a precise chemical tool to dissect metabolic pathways related to glucose metabolism and its downstream effects in various tissue types.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of related pharmaceutical products.

Basic Information

Product Name	Imirestat
CAS No.	89391-50-4
Molecular Formula	C₁₇H₁₆F₃N₃O₄
Molecular Weight	383.32 g/mol
Synonyms	Imirestat; (S)-6-Fluoro-2,3-dihydro-2',5'-dioxospiro[4H-1-benzopyran-4,4'-imidazolidine]-2-carboxamide; Sorbinil analog; ALO-4114; CTK8G7555; ZINC000003869756; (4S)-6-Fluoro-2,3-dihydro-2,5-dioxospiro[4H-1-benzopyran-4,4'-imidazolidine]-2'-carboxamide; Aldose Reductase Inhibitor I
EINECS	Contact for details

Quality Control

Every batch of Imirestat is manufactured and tested under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and reliability for your research and development processes. A detailed Certificate of Analysis (COA), confirming identity, purity, and potency, is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.