Description

Ici 174,864 is a selective, non-peptide antagonist of the delta opioid receptor (DOR). This compound is a critical research tool for neuropharmacological studies, enabling the investigation of opioid receptor subtypes and their roles in pain modulation, addiction, and mood disorders. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on central nervous system (CNS) drug discovery and neurobiological research.

Application

• Neuroscience Research: A standard pharmacological tool for studying the function and distribution of delta opioid receptors in the brain and spinal cord.
• Pain Mechanism Studies: Used to elucidate the specific role of DOR in pain pathways, aiding in the development of novel, targeted analgesics with potentially fewer side effects.
• Behavioral Pharmacology: Employed in animal models to investigate the effects of DOR antagonism on reward, addiction, depression, and anxiety-related behaviors.
• Drug Discovery Screening: Serves as a reference compound in high-throughput screening assays to identify and characterize new DOR ligands.
• Biochemical Assays: Used in receptor binding and functional assays (e.g., GTPγS) to determine the affinity and efficacy of test compounds at the DOR.
• Signal Transduction Research: Helps in mapping the downstream intracellular signaling pathways activated or inhibited by delta opioid receptor engagement.

Basic Information

Product Name	Ici 174,864
CAS No.	89352-67-0
Molecular Formula	C23H30N2O4
Molecular Weight	398.50 g/mol
Synonyms	ICI-174864; ICI 174864; N,N-Diallyl-Tyr-Aib-Aib-Phe-Leu-OH (where Aib = α-aminoisobutyric acid); H-Tyr-D-Ala-Phe-Leu-OH (depsipeptide analog); Delta Opioid Receptor Antagonist ICI-174864; δ-Opioid receptor antagonist ICI-174864; (2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-methylpropanoyl]amino]-2-methylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
EINECS	Contact for details

Quality Control

Our Ici 174,864 is produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and MS and NMR for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Solubility	Soluble in DMSO, ethanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.