Description

α,β-Methyleneadenosine 5'-Diphosphate Monosodium Salt is a chemically modified nucleotide analog that serves as a potent and selective inhibitor of certain nucleotide-metabolizing enzymes. This high-purity biochemical is critical for researchers and developers in life sciences, providing a reliable tool for mechanistic studies and assay development. It is primarily utilized by pharmaceutical R&D teams, diagnostic manufacturers, and academic institutions focused on enzymology, metabolic pathway analysis, and drug discovery.

Application

• Enzyme Inhibition Studies: Used as a potent, non-hydrolyzable competitive inhibitor for enzymes like adenylate kinase and other ATP/ADP-utilizing enzymes.
• Biochemical Research Reagent: Serves as a critical tool in studying nucleotide binding sites, enzyme kinetics, and signal transduction pathways.
• Pharmaceutical Development: Employed in high-throughput screening (HTS) assays to identify and characterize novel therapeutic compounds targeting nucleotide metabolism.
• Diagnostic Kit Manufacturing: Incorporated as a key component in enzymatic assay kits for clinical diagnostics and research use.
• Metabolic Pathway Analysis: Facilitates the investigation of cellular energy metabolism and purinergic signaling mechanisms.
• Structural Biology: Used in X-ray crystallography and NMR studies to elucidate enzyme-substrate complex structures.

Basic Information

Product Name	α,β-Methyleneadenosine 5'-Diphosphate Monosodium Salt
CAS No.	89016-30-8
Molecular Formula	C11H14N5O10P2Na
Molecular Weight	485.19 g/mol
Synonyms	α,β-Methylene-ADP sodium salt; Adenosine 5'-[α,β-methylene]diphosphate monosodium salt; AMP-CP sodium salt; AOPCP sodium salt; (α,β-Methylene)adenosine 5'-diphosphate sodium; ApCH2ppNa; NSC 368194; Methylene-ADP Na
EINECS	Contact for details

Quality Control

Our α,β-Methyleneadenosine 5'-Diphosphate Monosodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing purity, identity, and impurity profiles to ensure compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the product to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.