Description

Bafilomycin C1 CAS NO 88979-61-7 is a specific, naturally occurring macrolide antibiotic belonging to the bafilomycin family. This compound is a valuable biochemical tool and research standard due to its potent and specific inhibition of vacuolar-type H+-ATPase (V-ATPase) activity. It is primarily utilized by researchers and developers in the life sciences sector for investigating cellular processes like autophagy, intracellular trafficking, and lysosomal function. Its high specificity makes it an essential reagent for mechanistic studies in cell biology and pharmacology.

Application

• Biochemical Research: As a highly specific inhibitor of V-ATPase for studying lysosome acidification, autophagy, and organelle function in cell culture models.
• Pharmacology & Drug Discovery: Used as a reference standard in screening assays to identify novel compounds targeting V-ATPase or related pathways for therapeutic development.
• Cell Signaling Studies: Employed to dissect signaling pathways dependent on endosomal and lysosomal pH, including receptor-mediated endocytosis and nutrient sensing (e.g., mTOR pathway).
• Antibiotic Mechanism Research: Serves as a model compound for studying the structure-activity relationships of macrolide antibiotics and their interactions with biological targets.
• Academic & Institutional Laboratories: A critical tool for basic research in universities and research institutes focused on cell biology, microbiology, and molecular physiology.
• Biotech & Pharmaceutical R&D: Used in pre-clinical research to validate targets and understand the role of V-ATPase in disease models, such as cancer and neurodegenerative disorders.

Basic Information

Product Name	Bafilomycin C1
CAS No.	88979-61-7
Molecular Formula	C₃₅H₅₈O₉
Molecular Weight	622.83 g/mol
Synonyms	Bafilomycin C1; Bafilomycin C; BafC1; Antibiotic Bafilomycin C1; (3S,6S,7R,10R,11S,12S,13R,16S,19S,22R,23E,25E,27E,29E,31S,32R,33S,35R)-33-[(2S,3S,4S,5S,6R)-4-Amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-6,7,10,11,12,13,16,19,22,25,26,27,28,29,31,32,33,34,35-nonadecahydro-3,10,12,16,19,32-hexahydroxy-7,11,13,31-tetramethyl-5,8,20,23,30-pentaoxo-9,21-dioxa-4-azapentacyclo[30.2.1.1²,⁵.1¹⁴,¹⁷.1²⁰,²³]pentatriaconta-1(34),2(35),14,17,23,25,27,29-octaen-35-yl acetate; Baf C1
EINECS	Contact for details

Quality Control

Our Bafilomycin C1 is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in DMSO, Ethanol, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.