Description

Isocarbacyclin CAS NO 88931-59-3 is a stable synthetic analog of prostacyclin (PGI2), a potent vasodilator and inhibitor of platelet aggregation. This compound is valued for its enhanced chemical stability compared to the natural prostaglandin, making it a crucial tool for pharmacological research and development. It is primarily utilized by pharmaceutical researchers and life science companies investigating cardiovascular diseases, pulmonary hypertension, and thrombosis.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies of vascular tone, platelet function, and smooth muscle relaxation.
• Drug Discovery & Development: Serves as a key intermediate or lead compound in the development of novel therapeutics targeting prostacyclin receptor (IP receptor) pathways.
• Biochemical Assays: Employed in in vitro and cell-based assays to study cyclic AMP (cAMP) signaling and other downstream effects of IP receptor activation.
• Cardiovascular Disease Models: Applied in experimental models to investigate potential treatments for conditions like pulmonary arterial hypertension (PAH) and peripheral vascular disease.
• Academic Research: A fundamental reagent for university and institutional labs exploring prostaglandin biology, receptor pharmacology, and signal transduction mechanisms.

Basic Information

Product Name	Isocarbacyclin
CAS No.	88931-59-3
Molecular Formula	C₂₁H₃₂O₅
Molecular Weight	364.48 g/mol
Synonyms	9α-Methyl-6,9α-methano-δ⁶(9α)-PGI₁; (5Z)-9α-Methyl-6,9α-methano-δ⁶(9α)-PGI₁; 9-Methylene PGI₂; Isocarbacyclin methyl ester (common starting material); Cicaprost analog; Stable prostacyclin analog; PGI₂ analog; ZK 36374 (historical code)
EINECS	Contact for details

Quality Control

Our Isocarbacyclin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for purity, identity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep the material in its original packaging until use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.