Description

Bafilomycin B2 CAS NO 88907-48-6 is a potent and specific macrolide antibiotic belonging to the bafilomycin family, known for its role as a highly selective inhibitor of vacuolar-type H+-ATPase (V-ATPase). This compound is crucial for researchers investigating intracellular pH regulation, autophagy, and vesicular trafficking pathways. It is an essential biochemical tool for pharmaceutical R&D, academic research, and biotechnology applications focused on cancer biology, neurodegenerative diseases, and lysosomal function.

Application

• Biochemical Research: A key reagent for studying V-ATPase function, lysosomal acidification, and organelle pH homeostasis in cell biology experiments.
• Pharmaceutical Development: Used as a reference standard and pharmacological probe in drug discovery programs targeting autophagy, osteoclast function, and cancer metastasis.
• Academic Studies: Employed in neuroscience research to investigate the role of vesicular acidification in neurotransmitter storage and release.
• Microbiology: Serves as a tool compound for studying the mode of action of macrolide antibiotics and bacterial resistance mechanisms.
• Signal Transduction Research: Utilized to dissect cellular signaling pathways that are dependent on proper endosomal and lysosomal function.

Basic Information

Product Name	Bafilomycin B2
CAS No.	88907-48-6
Molecular Formula	C₃₅H₅₈O₉
Molecular Weight	622.83 g/mol
Synonyms	Bafilomycin B2; Bafilomycin B 2; Baf B2; Antibiotic Bafilomycin B2; V-ATPase Inhibitor Bafilomycin B2; (3S,6S,7R,10R,11S,12S,13R,16S,19S,22R,23S,26R,27R,33aS)-7,11,13,22,23,26-Hexahydroxy-3-[(1R)-1-hydroxyethyl]-6,10,12,16,19,23,27-heptamethyl-4,20,28-trioxo-9,30-dioxa-21-azatetracyclo[23.3.1.1¹⁶,¹⁹.0⁵,²⁹]triaconta-1(28),5(29),24,26-tetraen-2-yl (2E,4E)-6-methylocta-2,4-dienoate
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Quality Control

Our Bafilomycin B2 is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and NMR for structural verification, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, keep under inert atmosphere. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, ethanol, methanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.