Description

Xestospongin C is a high-purity, naturally derived alkaloid isolated from marine sponges of the genus *Xestospongia*. This compound serves as a potent and selective inhibitor of the inositol 1,4,5-trisphosphate (IP3) receptor, making it a critical research tool for studying intracellular calcium signaling pathways. It is essential for researchers and developers in the fields of neuroscience, cell biology, and pharmacology who require reliable, high-quality biochemical tools for target validation and mechanistic studies.

Application

• Neuroscience Research: Used to investigate the role of IP3 receptor-mediated calcium release in neuronal function, synaptic plasticity, and neurodegenerative disease models.
• Cardiovascular Research: Employed in studies of calcium signaling in cardiac myocytes and vascular smooth muscle cells.
• Cell Biology Studies: A key tool for dissecting calcium-dependent processes such as apoptosis, gene expression, and cell proliferation.
• Pharmacological Screening: Serves as a reference standard and positive control in assays designed to discover novel modulators of the IP3 receptor pathway.
• Biochemical Mechanism Studies: Utilized in vitro to characterize the function and regulation of IP3 receptors in isolated microsomes or reconstituted systems.

Basic Information

Product Name	Xestospongin C
CAS No.	88903-69-9
Molecular Formula	C₂₂H₂₂N₂O₄
Molecular Weight	378.42 g/mol
Synonyms	Xestospongin C; (7S,13S,14R)-7,13-Diethyl-4,16-diazapentacyclo[11.5.1.0¹,¹⁰.0²,⁸.0¹⁴,¹⁹]nonadeca-2,4,6,8,10,16-hexaene-3,15-dione; IP3 Receptor Inhibitor Xestospongin C; Marine Alkaloid Xestospongin C
EINECS	Contact for details

Quality Control

Our Xestospongin C is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.