Description

Bafilomycin A1 CAS NO 88899-55-2 is a potent and highly specific macrolide antibiotic that functions as a vacuolar-type H+-ATPase (V-ATPase) inhibitor. This compound is a critical research tool for studying intracellular vesicle trafficking, autophagy, and lysosomal function. It is essential for researchers and developers in the fields of cell biology, pharmacology, and biochemistry who require a reliable, high-purity reagent for mechanistic studies and assay development.

Application

• Biochemical Research: As a selective V-ATPase inhibitor to study lysosomal acidification, endocytosis, and intracellular pH regulation.
• Autophagy Studies: Used to block the fusion of autophagosomes with lysosomes, a key step in the autophagy pathway.
• Cancer Research: Investigated for its potential to induce apoptosis in various cancer cell lines by disrupting lysosomal activity.
• Microbiology: Employed in studies of bacterial toxin trafficking and the mode of action of other pathogens.
• Neuroscience: Applied in research on neurotransmitter storage and release mechanisms within synaptic vesicles.
• Drug Discovery: Serves as a reference compound and pharmacological tool in high-throughput screening for novel V-ATPase inhibitors.

Basic Information

Product Name	Bafilomycin A1
CAS No.	88899-55-2
Molecular Formula	C35H58O9
Molecular Weight	622.83 g/mol
Synonyms	Bafilomycin A1; BafA1; V-ATPase Inhibitor; (1R,3S,5S,7R,8E,12Z,15R,16R)-15-[(2S,3S,4R,5S)-3,4-Dihydroxy-5-methyl-6-(methylamino)oxan-2-yl]oxy-5,16-dihydroxy-3,7,11,15-tetramethyl-16-(2-methylbutanoyl)oxyoxacyclohexadeca-8,12-dien-2-one; Antibiotic Bafilomycin A1; NSC 381476
EINECS	Contact for details

Quality Control

Our Bafilomycin A1 is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.