Description

8-Oxo-2'-Deoxyguanosine is a significant oxidized derivative of the DNA nucleoside 2'-deoxyguanosine, widely recognized as a biomarker for oxidative stress and DNA damage. This compound is essential for research into the mechanisms of mutagenesis, aging, and various disease pathologies. It is a critical reagent for scientists and manufacturers in the fields of analytical biochemistry, diagnostic kit development, and pharmaceutical research, where precise quantification of oxidative damage is required.

Application

• Biomarker Standard for Oxidative Stress: Used as a primary analytical standard in HPLC-MS, LC-MS/MS, and ELISA methods to quantify 8-oxo-dG levels in biological samples (urine, blood, tissue).
• DNA Damage and Repair Studies: Essential for in vitro and in vivo research investigating the formation and repair mechanisms of oxidative DNA lesions.
• Diagnostic Kit Development: Serves as a key component in the development and calibration of commercial diagnostic kits for assessing oxidative stress status.
• Pharmaceutical & Nutraceutical Research: Employed in screening and efficacy studies of antioxidants, chemopreventive agents, and radioprotective drugs.
• Toxicology and Environmental Health: Used to assess the genotoxic impact of chemicals, radiation, and environmental pollutants.
• Aging and Disease Mechanism Research: Applied in studies related to cancer, neurodegenerative diseases (e.g., Alzheimer's, Parkinson's), and metabolic disorders.
• Reference Material for Quality Control: Acts as a high-purity reference compound for ensuring accuracy in clinical and research laboratories.

Basic Information

Product Name	8-Oxo-2'-Deoxyguanosine
CAS No.	88847-89-6
Molecular Formula	C10H13N5O5
Molecular Weight	283.24 g/mol
Synonyms	8-Oxo-deoxyguanosine; 8-Hydroxy-2'-deoxyguanosine; 8-OH-dG; 8-oxo-dG; 7,8-Dihydro-8-oxo-2'-deoxyguanosine; Oxo8dG; 8-Oxo-7,8-dihydro-2'-deoxyguanosine
EINECS	Contact for details

Quality Control

Our 8-Oxo-2'-Deoxyguanosine is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive analytical and research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant GMP and ISO 9001 standards for laboratory reagents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be kept under anhydrous conditions. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.